Vitamin E and neurodegenerative disorders associated with oxidative stress.
Butterfield DA, Castegna A, Drake J, Scapagnini G, Calabrese V
Nutr Neurosci 2002 Sep 5:229-39
Abstract
Several neurodegenerative disorders are associated with oxidative stress
that is manifested by lipid peroxidation, protein oxidation and other
markers. Included in these disorders in which oxidative stress is thought to
play an important role in their pathogenesis are Alzheimer's disease (AD),
Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), tardive
dyskinesia, Huntington's disease (HD), and multiple sclerosis. This review
presents some of the chemistry of vitamin E as an antioxidant and summarizes
studies in which vitamin E has been employed in these disorders and models
thereof.
Author Address
Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown
Center on Aging, University of Kentucky, Lexington 40506, USA.
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